The DEXD/H-box RNA Helicase DDX19 Is Regulated by an α-Helical Switch
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چکیده
منابع مشابه
The DEXD/H-box RNA Helicase DDX19 Is Regulated by an α-Helical Switch*S⃞
DEXD/H-box RNA helicases couple ATP hydrolysis to RNA remodeling by an unknown mechanism. We used x-ray crystallography and biochemical analysis of the human DEXD/H-box protein DDX19 to investigate its regulatory mechanism. The crystal structures of DDX19, in its RNA-bound prehydrolysis and free posthydrolysis state, reveal an alpha-helix that inserts between the conserved domains of the free p...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.c900018200